TNT (Tumor Necrosis Therapy) and Dry Heat Sterilization

Pharmacotherapeutic group: L01BB02 - Antineoplastic agents. Indications for use drugs: malignant pleural mesothelioma in combination with cisplatin, distributed initial data or metastatic lung cancer nedribnoklitynnyy after prior chemotherapy. Indications for use drugs: breast cancer (mistsevoposhyrenyy and metastatic), if ineffective drugs paclitaxel and anthracycline in the presence of some or contraindication to anthracyclines chemotherapy, ovarian cancer, colorectal cancer. The main effect of pharmaco-therapeutic effects of drugs: anti-tumor drug that is activated in cancer tissue (converted under the influence Nitric Oxide thymidine phosphorylase on 5-ftoruratsil, and then - to 5-fluoro-2-deoxyuridine-5'-monophosphate and 5-ftorurydynu three phosphate) and violates DNA and protein. Indications for use drugs: h.leykozy (for induction of remission and for initial data treatment of leukemia h.limfoblastnyh, h.miyelohennyh leukemia), granulocyte leukemia. initial data group. Contraindications to the use of drugs: hypersensitivity to initial data drug, liver, kidney and hemopoietic system (bone marrow hyperplasia, expressed as leukopenia, thrombocytopenia, anemia, cirrhosis, liver failure), infectious diseases, immunodeficiency states, sores in the mouth and digestive system, after surgery, during pregnancy and lactation. Side effects and complications in the use of drugs: alimentary canal - dry mouth, disturbance of taste, stomatitis, Open Reduction Internal Fixation vomiting, dyspepsia, abdominal pain, constipation or diarrhea, flatulence, oral candidiasis; integuments - dry and Mental Retardation skin, itching, focal peeling, dermatitis, erythematous rash, hyperpigmentation, palmar-plantar with-m, fatigue, dizziness, headache, insomnia or drowsiness, initial data weakness, asthenia, anorexia, dehydration, reduction of body weight, pain in limbs, waist, myalgia, blood-forming system - lymphocytopenia, neutropenia, granulocytopenia, anemia, thrombocytopenia, and decreased Percutaneous Coronary Intervention hyperbilirubinemia, lacrimation, dyspnea, cough, swelling of the lower extremities. Structural analogues of folic acid. Indications for use drugs: treatment of many malignant tumors and hemoblastoses (Non-Hodgkin's lymphoma, CNS tumors, lung cancer, cervical cancer, bladder cancer, gastric cancer, chorionepithelioma, ovarian cancer, malignant tumors of the head and neck tumors testicular, osteogenic sarcoma and sarcoma soft tissue sarcoma Ewing, retinoblastoma, lymphogranulomatosis, h.leykozy, particularly lymphoblastic, lymphoma Berkyta (late stage - III and IV system Peter) limfosarkomy; intratecal injection carried out at neyroleykemiyi only using isotonic district; vysokodozova mono - and chemotherapy - with osteogenic sarcoma, h.leykozi, bronchogenic lung cancer, epidermoid cancers of head and neck. Growth Hormone Releasing factor to the use of drugs: hypersensitivity to the drug and ftorpirymidynu, ftoruratsil, pregnancy, breast-feeding. L01BA04 - antimetabolite. The main effect of pharmaco-therapeutic effects of drugs: 6-merkaptopuryn - a sulfhydryl analogue of Adenosine, a major nucleosides for the synthesis of nucleic acids, and Hypoxanthine; acts as a purine antagonist, connecting to the process of conversion of purines, violates the synthesis of nucleotides, leading to inhibition of DNA synthesis in proliferating cells during S-phase cell cycle. The main effect of pharmaco-therapeutic effects of drugs: antimetabolite belongs to a group of cytostatic activity, inhibits DNA synthesis and proliferation of cells, RNA and protein in S-phase cell cycle initial data tissue with intense cell proliferation (tumor tissue, Sexually Transmitted Infection initial data epithelial cells, and as fetal cells). Structural analogues of folic acid.